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Abstract
Urolithin A (UA) is generated by gut microbiota and may influence various degenerative diseases.
- UA exerts multi-target biological effects through the regulation of pathways related to inflammation, oxidative stress, cell death, and mitochondrial health.
- In vitro and animal studies suggest UA may affect processes related to musculoskeletal diseases, cardiovascular diseases, neurological disorders, and cancers.
- Current human clinical evidence on UA is preliminary, focusing on muscle function, exercise outcomes, and metabolic biomarkers.
- Safety and tolerability of UA have been assessed in short- to medium-term studies.
- The bioavailability of UA is influenced by individual gut microbiota metabolic profiles.
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