Gut-brain nerve pathway involved in stomach juice release triggered by eating in mice

Vagal gut-brain-gut pathways are crucial for regulating gastric secretion during meals.

• Stomach-innervating vagal afferents are essential for gastric secretion.
• Specific neurons, including Glp1r+ and Sst+, are responsible for driving acid, pepsin, and gastrin secretion.
• Conditional deletion of Piezo2 in Glp1r+ mechanosensory afferents reduced secretion triggered by stomach distension.
• Genetically defined vagal motor-neuron subsets exhibit distinct roles in secretion, with Cck+ neurons increasing multiple secretions and Grp+ neurons primarily affecting acid secretion.
• Calb2+ neurons in the enteric circuit drive secretion while minimally impacting motility.

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