Full text is available at the source.
Abstract
Orally administered vanillin improved cognitive performance in a mouse model of circadian disruption.
- Circadian disruption impaired spatial learning and recognition memory in mice.
- Vanillin corrected abnormal changes in tryptophan-related metabolites, including tryptophan, kynurenine, and kynurenic acid.
- Vanillin modulated the composition and diversity of gut microbiota.
- Intestinal barrier function was enhanced and immune homeostasis improved with vanillin treatment.
- Vanillin regulated proteins in the hippocampus related to neuronal and synaptic function while reducing astrocyte activation.
Simplified