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Abstract
Essence
Anti-CD31 targeted VE-cadherin mRNA LNPs reduced vascular leakage in mouse models of lung edema and ischemic stroke.
Evidence
This was a preclinical mRNA-delivery study in multiple mouse vascular hyperpermeability models, where a single aCD31/tLNP-VEc dose reduced fluid extravasation and macrophage infiltration in bleomycin lung edema and cut post-stroke brain plasma protein leakage by 50%.
Caveat
The study is limited to mouse models and acute permeability endpoints, so human benefit, dosing window, and safety were not tested.
Simplified
mRNA Technology