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Abstract
Glycometabolic reprogramming in key vascular cells may significantly influence atherosclerosis progression.
- Alterations in glucose metabolism within macrophages, endothelial cells, and vascular smooth muscle cells are linked to plaque development.
- Changes in metabolic processes can modulate inflammatory activation, oxidative stress, and lipid metabolism.
- Key pathways involved in atherosclerosis include glycolysis, the pentose phosphate pathway, and lactate-mediated epigenetic regulation.
- Metabolic alterations may interact with immune responses, trained immunity, epigenetic changes, and cellular aging.
- Potential therapeutic targets include glycolytic enzymes and specific metabolic-epigenetic pathways.
- Challenges remain in achieving specificity and selectivity for therapeutic interventions in this context.
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