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Evidence for roles of vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase activating polypeptide (PACAP) receptors in modulating the responses of rat dorsal horn neurons to sensory inputs
Roles of VIP and PACAP receptors in controlling rat spinal neurons' responses to sensory signals
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Abstract
Ionophoretic administration of vasoactive intestinal polypeptide (VIP) or pituitary adenylate cyclase activating polypeptide (PACAP)-38 significantly increased the electrophysiological activity of single multireceptive dorsal horn neurons.
- Some neurons responded selectively to PACAP-38, indicating possible mediation by a PACAP receptor.
- Other neurons responded to both VIP and PACAP-38, suggesting involvement of VIP1 and/or VIP2 receptors.
- Most non-nociceptive neurons did not respond to PACAP-38, and all were unaffected by VIP.
- VIP/PACAP receptor antagonists inhibited multireceptive cell responses to both innocuous and noxious stimuli.
- The selectivity of the antagonists points towards the involvement of VIP1 and PACAP receptors, though VIP2 receptors may also play a role.
- These findings indicate that VIP and PACAP may regulate how multireceptive dorsal horn neurons respond to sensory stimuli.
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