Neuropeptides

Roles of VIP and PACAP receptors in controlling rat spinal neurons' responses to sensory signals

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Ionophoretic administration of vasoactive intestinal polypeptide (VIP) or pituitary adenylate cyclase activating polypeptide (PACAP)-38 significantly increased the electrophysiological activity of single multireceptive dorsal horn neurons.

  • Some neurons responded selectively to PACAP-38, indicating possible mediation by a PACAP receptor.
  • Other neurons responded to both VIP and PACAP-38, suggesting involvement of VIP1 and/or VIP2 receptors.
  • Most non-nociceptive neurons did not respond to PACAP-38, and all were unaffected by VIP.
  • VIP/PACAP receptor antagonists inhibited multireceptive cell responses to both innocuous and noxious stimuli.
  • The selectivity of the antagonists points towards the involvement of VIP1 and PACAP receptors, though VIP2 receptors may also play a role.
  • These findings indicate that VIP and PACAP may regulate how multireceptive dorsal horn neurons respond to sensory stimuli.

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