Vasoactive intestinal polypeptide (VIP) phase‐shifts the rat suprachiasmatic nucleus clock in vitro

Feb 24, 2001The European journal of neuroscience

Vasoactive intestinal polypeptide shifts the timing of the rat's brain internal clock in a lab setting

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Abstract

Application of vasoactive intestinal polypeptide (VIP) during the early or late subjective night resulted in a small phase delay or a large phase advance, respectively, in rat SCN neuron firing rates.

  • VIP does not shift the peak firing rate rhythm when applied during the subjective day.
  • The phase-advancing effect of VIP is attributed to the VPAC(2) receptor, as shown with the selective agonist RO 25-1553.
  • Neither the PAC(1) receptor agonist nor the VPAC(1) receptor agonist produced a similar phase-resetting effect.
  • VIP phase-dependently resets the electrical activity rhythm of SCN neurons in vitro.
  • The findings suggest a potential role for VIP and the VPAC(2) receptor in synchronizing the rodent circadian clock with light.

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