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Abstract
Voltage-dependent anion channel 2 (VDAC2) is essential for mitochondrial function and is linked to various human diseases.
- VDAC2 regulates the transport of key molecules such as ATP, ADP, NADPH, and calcium, which are vital for energy metabolism and cellular functions.
- Dysfunction or abnormal expression of VDAC2 is associated with tumorigenesis, neurodegenerative diseases, and cardiovascular disorders.
- VDAC2 plays a critical role in apoptosis regulation and is involved in processes like ferroptosis, necroptosis, and mitophagy.
- Pharmacological compounds targeting VDAC2 have been developed, offering tools for studying mitochondrial dysfunction-related diseases.
- Challenges exist in achieving isoform selectivity, developing tissue-specific models, and understanding conservation across species.
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