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Separate ON and OFF pathways in vertebrate vision first arose during the Cambrian
ON and OFF visual pathways in vertebrates first appeared during the Cambrian period
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Abstract
Retinal ON and OFF bipolar cells, along with novel metabotropic glutamate receptors, are present in lamprey.
- The study identifies the presence of distinct ON and OFF bipolar cells in lamprey.
- Novel metabotropic glutamate receptors are found on the dendrites of ON bipolar cells.
- The findings suggest that separate ON and OFF visual pathways may have originated in the vertebrate visual system over 500 million years ago during the late Cambrian.
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