Light-Activated Hydrogels with Exosomes Help Heal Deep Skin Wounds by Supporting All Healing Stages

The all-in-one OD/GM/QCS@Exo hydrogel demonstrated significant wound-healing promotion effects.

• The hydrogel was prepared with catechol-modified oxidized hyaluronic acid, methylacrylylated gelatin, and quaternized chitosan.
• Cross-linking was achieved using visible light, which enhanced injectability and biocompatibility.
• Strong adhesion and mechanical strength were attributed to the incorporation of catechol groups and multicross-linked networks.
• Antibacterial, anti-inflammatory, and antioxidant properties were observed in the hydrogel.
• The hydrogel-mediated release of exosomes significantly promoted cellular proliferation, migration, and the formation of new blood vessels.

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