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Concurrent vitamin D supplementation and exercise training improve cardiac fibrosis via TGF-β/Smad signaling in myocardial infarction model of rats
Vitamin D and exercise together reduce heart scarring through TGF-beta/Smad signaling in rats after heart attack
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Abstract
The highest ejection fraction (EF) and lowest TGF-β1 expression were observed in the myocardial infarction group receiving both vitamin D and aerobic-resistance training.
- Concurrent vitamin D supplementation and aerobic-resistance training (ART) may improve cardiac function in rats with myocardial infarction.
- Significant reductions in cardiac TGF-β1, Smad2/3, and collagen I/III expressions were noted with combined treatment.
- Functional exercise capacity and strength gain were highest in the groups receiving both vitamin D and ART.
- The study suggests that combining vitamin D with ART could alleviate myocardial fibrosis.
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