A 12-week double-blind randomized clinical trial of vitamin D₃ supplementation on body fat mass in healthy overweight and obese women.

Sep 25, 2012Nutrition journal

Vitamin D3 supplementation may affect body fat in healthy overweight and obese women over 12 weeks.

AI simplified

Abstract

Serum 25(OH)D concentrations increased by 38.2 ± 32.7 nmol/L in the vitamin D group compared to 4.6 ± 14.8 nmol/L in the placebo group.

Vitamin D3 supplementation resulted in a significant decrease in body fat mass of -2.7 ± 2.1 kg compared to -0.47 ± 2.1 kg in the placebo group.
Serum iPTH concentrations decreased by vitamin D3 supplementation, showing a change of -0.26 ± 0.57 pmol/L versus 0.27 ± 0.56 pmol/L in the placebo group.
No significant changes were observed in body weight or waist circumference between the two groups.
A significant reverse correlation was found between changes in serum 25(OH)D concentrations and body fat mass (r = -0.319, P = 0.005).

AI simplified

BACKGROUND: Vitamin D concentrations are linked to body composition indices, particularly body fat mass. Relationships between hypovitaminosis D and obesity, described by both BMI and waist circumference, have been mentioned. We have investigated the effect of a 12-week vitamin D3 supplementation on anthropometric indices in healthy overweight and obese women.

METHODS: In a double-blind, randomized, placebo-controlled, parallel-group trial, seventy-seven participants (age 38 ± 8.1 years, BMI 29.8 ± 4.1 kg/m²) were randomly allocated into two groups: vitamin D (25 μg per day as cholecalciferol) and placebo (25 μg per day as lactose) for 12 weeks. Body weight, height, waist, hip, fat mass, 25(OH) D, iPTH, and dietary intakes were measured before and after the intervention.

RESULTS: Serum 25(OH)D significantly increased in the vitamin D group compared to the placebo group (38.2 ± 32.7 nmol/L vs. 4.6 ± 14.8 nmol/L; P<0.001) and serum iPTH concentrations were decreased by vitamin D3 supplementation (-0.26 ± 0.57 pmol/L vs. 0.27 ± 0.56 pmol/L; P<0.001). Supplementation with vitamin D3 caused a statistically significant decrease in body fat mass in the vitamin D group compared to the placebo group (-2.7 ± 2.1 kg vs. -0.47 ± 2.1 kg; P<0.001). However, body weight and waist circumference did not change significantly in both groups. A significant reverse correlation between changes in serum 25(OH) D concentrations and body fat mass was observed (r = -0.319, P = 0.005).

CONCLUSION: Among healthy overweight and obese women, increasing 25(OH) D concentrations by vitamin D3 supplementation led to body fat mass reduction.

Full Text

We can’t show the full text here under this license. Use the link below to read it at the source.

View full text (PDF) ↗View full text (HTML) ↗View full text ↗

Abstract

Full Text

what lands in your inbox each week: