Case reports in neurology

Nerve Weakness Causing Foot Drop Linked to Leg Crossing After Weight Loss with Tirzepatide

Updated

Abstract

Two patients experienced foot drop associated with rapid weight loss from tirzepatide treatment.

  • Common peroneal nerve palsy, also known as 'slimmer's palsy,' may occur after significant weight loss.
  • Both cases involved habitual leg crossing, which could contribute to nerve compression.
  • Foot drop was observed following the weight loss induced by tirzepatide, suggesting a potential link.
  • The effects of rapid weight loss on nerve health warrant further investigation.

Simplified

Full Text

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Funding

Competing interests

Dr. Jacob O. Levitt has been on advisory boards for Pfizer, Lilly, and Takeda. Ms. Ann I. Tanyous has no conflicts of interest to declare.
PubMed

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