Elucidating the role of weight loss and glycaemic control in patients with type 2 diabetes

In a study of 8876 patients with newly diagnosed type 2 diabetes, each 1% reduction in body mass index was associated with a 3% reduced risk of heart failure.

• Each 1% reduction in body mass index was associated with a 1% reduced risk of hypertension and a 4% reduced risk of requiring insulin initiation.
• Each 1% reduction in glycated haemoglobin (HbA1c) was associated with a 4% reduced risk of hypertension and a 29% reduced risk of insulin initiation.
• For patients initiating treatment with glucagon-like peptide-1 receptor agonists (GLP-1RAs), each 1% reduction in body mass index was linked to a 4% reduced risk of cardiovascular disease.
• In this cohort, each 1% reduction in HbA1c was associated with a 4% reduced risk of chronic kidney disease.
• Lower variability and greater durability in body mass index were linked to decreased risk of adverse clinical outcomes in both patient cohorts.

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