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Abstract
No molecular signature specific to Long-COVID has been identified in patients with diverse symptoms.
- Long-COVID is associated with debilitating physical and cognitive deficits.
- Previous studies have not reported comparisons of Long-COVID with fibrosis-related epigenetic changes.
- A subset of DNA methylation changes may be present in Long-COVID patients from multiple cohorts.
- These changes could predominate in specific immune or inflammatory cell types.
- There may be an overlap between the epigenetic profile of Long-COVID patients and those at risk for pulmonary fibrosis.
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