WIF1 was downregulated in cervical cancer due to promoter methylation

WIF1 expression is significantly lower in cervical cancer tissues compared to adjacent normal cervical tissues.

• The WIF1 promoter is methylated in the cervical cancer SiHa cell line but not in the normal cervical epithelial cell line Ect1.
• WIF1 mRNA and protein levels are significantly reduced in SiHa cells relative to Ect1 cells.
• Treatment with 5-aza-2-deoxycytidine (AZA) increases WIF1 mRNA and protein levels in SiHa cells.
• AZA treatment induces apoptosis and inhibits invasion in SiHa cells, effects that are reversed by WIF1 siRNA.
• Methylation of the WIF1 promoter is associated with the downregulation of WIF1 and activation of Wnt/β-catenin signaling in cervical cancer.

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