A minireview of 1,2,3‐triazole hybrids with O‐heterocycles as leads in medicinal chemistry

Sep 30, 2021Chemical biology & drug design

Overview of 1,2,3-triazole compounds combined with oxygen-containing rings as promising drug candidates

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Abstract

Triazole compounds show diverse therapeutic potential, including various pharmacological applications.

Triazole skeletons are significant structural components in drugs with anti-cancer, anti-bacterial, anti-fungal, anti-viral, anti-oxidant, anti-inflammatory, anti-diabetic, anti-tubercular, and anti-depressant properties.
Recent synthesis of triazole hybrids with different heterocyclic moieties aims to enhance pharmacological profiles and address issues like drug resistance and toxicity.
Several triazole hybrids are commercially available and effective against various infections, including tazobactam and cefatrizine as anti-bacterial agents, and isavuconazole and ravuconazole for anti-fungal activities.
The review summarizes the biological activities of 1,2,3-triazole hybrids with oxygen-containing heterocycles, highlighting their relevance in medicinal chemistry.

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Over the past few decades, the dynamic progress in the synthesis and screening of heterocyclic compounds against various targets has made a significant contribution in the field of medicinal chemistry. Among the wide array of heterocyclic compounds, triazole moiety has attracted the attention of researchers owing to its vast therapeutic potential and easy preparation via copper and ruthenium-catalyzed azide-alkyne cycloaddition reactions. Triazole skeletons are found as major structural components in a different class of drugs possessing diverse pharmacological profiles including anti-cancer, anti-bacterial, anti-fungal, anti-viral, anti-oxidant, anti-inflammatory, anti-diabetic, anti-tubercular, and anti-depressant among various others. Furthermore, in the past few years, a significantly large number of triazole hybrids were synthesized with various heterocyclic moieties in order to gain the added advantage of the improved pharmacological profile, overcoming the multiple drug resistance and reduced toxicity from molecular hybridization. Among these synthesized triazole hybrids, many compounds are available commercially and used for treating different infections/disorders like tazobactam and cefatrizine as potent anti-bacterial agents while isavuconazole and ravuconazole as anti-fungal activities to name a few. In this review, we will summarize the biological activities of various 1,2,3-triazole hybrids with copious oxygen-containing heterocycles as lead compounds in medicinal chemistry. This review will be very helpful for researchers working in the field of molecular modeling, drug design and development, and medicinal chemistry.

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A minireview of 1,2,3‐triazole hybrids with O‐heterocycles as leads in medicinal chemistry

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