Lab and computer studies of 2,4-dichloro-5-(N-aryl/alkyl)sulfamoylbenzoic acid compounds for diabetes treatment potential

Compound 3c exhibits 3-fold inhibition of α-amylase and 5-fold inhibition of α-glucosidase compared to the standard drug acarbose.

• Synthesis of 2,4-dichloro-5-[(N-aryl/alkyl)sulfamoyl]benzoic acid derivatives was achieved through chlorosulfonation and subsequent reactions.
• Most synthesized compounds showed high inhibitory potential against α-glucosidase and α-amylase, comparable to the standard drug acarbose.
• Molecular docking studies indicated that these compounds may bind to the active site of the enzymes through hydrogen bonding and various pi interactions.
• In silico analysis suggested favorable drug-like properties for the synthesized compounds.

Simplified