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2,4-Dichloro-5-[(N-aryl/alkyl)sulfamoyl]benzoic Acid Derivatives: In Vitro Antidiabetic Activity, Molecular Modeling and In silico ADMET Screening
Lab and computer studies of 2,4-dichloro-5-(N-aryl/alkyl)sulfamoylbenzoic acid compounds for diabetes treatment potential
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Abstract
Compound 3c exhibits 3-fold inhibition of α-amylase and 5-fold inhibition of α-glucosidase compared to the standard drug acarbose.
- Synthesis of 2,4-dichloro-5-[(N-aryl/alkyl)sulfamoyl]benzoic acid derivatives was achieved through chlorosulfonation and subsequent reactions.
- Most synthesized compounds showed high inhibitory potential against α-glucosidase and α-amylase, comparable to the standard drug acarbose.
- Molecular docking studies indicated that these compounds may bind to the active site of the enzymes through hydrogen bonding and various pi interactions.
- In silico analysis suggested favorable drug-like properties for the synthesized compounds.
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