Molecular reproduction and development

Beta 2-agonist treatment increases uterine oxytocin receptor gene activity in pregnant rats

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Fenoterol administration led to a maximum 125% increase in oxytocin receptor mRNA expression in the late-pregnant rat uterus.

  • Hexoprenaline induced a maximum 24% increase of oxytocin receptor mRNA.
  • Fenoterol treatment resulted in a fourfold increase in oxytocin receptor mRNA in vitro.
  • The contractility effect of oxytocin on uterine rings was significantly enhanced in fenoterol-treated rats compared to intact term pregnant rats.
  • The EC50 values for oxytocin's effect on uterine contractility were not statistically different between the groups.
  • The increase in oxytocin receptor mRNA expression induced by Beta(2)-agonists may hinder the effectiveness of these drugs in treating preterm uterine contractions.

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