β2‐agonist treatment enhances uterine oxytocin receptor mRNA expression in pregnant rats

Jul 28, 2004Molecular reproduction and development

Beta 2-agonist treatment increases uterine oxytocin receptor gene activity in pregnant rats

AI simplified

Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

Fenoterol administration led to a maximum 125% increase in oxytocin receptor mRNA expression in the late-pregnant rat uterus.

  • Hexoprenaline induced a maximum 24% increase of oxytocin receptor mRNA.
  • Fenoterol treatment resulted in a fourfold increase in oxytocin receptor mRNA in vitro.
  • The contractility effect of oxytocin on uterine rings was significantly enhanced in fenoterol-treated rats compared to intact term pregnant rats.
  • The EC50 values for oxytocin's effect on uterine contractility were not statistically different between the groups.
  • The increase in oxytocin receptor mRNA expression induced by Beta(2)-agonists may hinder the effectiveness of these drugs in treating preterm uterine contractions.

AI simplified

Full Text

Full text is available at the source.
View full text ↗

Related papers

Sep '04
How Oxytocin Receptors Affect Uterine Contractions Differently Across the Mouse Reproductive Cycle
cited by 6 papers
research support, non-u.s. gov't
Mar '09
How induced diabetes affects drug- and electrical-stimulated uterine muscle contractions
top 30% journal
cited by 8 papers
research support, non-u.s. gov't
Dec '06
Oxytocin causes short and long muscle contractions controlled by the contraction system, not by oxytocin receptor amount
cited by 16 papers
research support, non-u.s. gov't
Mar '04
Estrogen increases oxytocin receptor gene activity in the muscle layer of non-pregnant human wombs outside the body
top 20% journal
cited by 58 papers
research support, non-u.s. gov't
Aug '06
Cigarette smoke extract increases oxytocin-induced rhythmic contractions in early labor muscle from rats and humans
top 20% journal
cited by 23 papers
journal article
Jul '97
RU486's effects on hormone levels and hormone receptors in the rat uterus late in pregnancy
cited by 59 papers
research support, non-u.s. gov't
Dec '95
Oxytocin receptor gene activity in the rat uterus during pregnancy, reproductive cycles, and hormone treatments
cited by 107 papers
research support, non-u.s. gov't

what lands in your inbox each week:

  • 📚7 fresh studies
  • 📝plain-language summaries
  • ✅direct links to original studies
  • 🏅top journal indicators
  • 📅weekly delivery
  • 🧘‍♂️always free

Recent issues from the circadian biology brief

issue #31
Artificial light at night disrupts bird sleep and metabolism across 675 studies
yesterday7 studies
issue #30
Your hair can reveal your circadian rhythm from a single sample
1 week ago7 studies
issue #29
Your body clock needs 25% more epidural painkiller at night
2 weeks ago7 studies
issue #28
Night owls have 123% higher mortality risk after age 81
3 weeks ago7 studies
issue #27
Light pollution linked to 31% higher diabetes risk in major analysis
4 weeks ago7 studies
issue #26
Wearables can detect early dementia signs with 70-95% accuracy across 200,000+ people
5 weeks ago7 studies
issue #25
Your brain's master clock has 7 distinct neuron types with specific jobs
6 weeks ago7 studies
issue #24
Sleep disruption in teens linked to altered circadian gene expression and future heart disease risk
7 weeks ago7 studies
issue #23
Morning-loaded eating suppresses ghrelin more than evening meals — and artificial light disrupts immune rhythms in wild rodents
8 weeks ago7 studies
issue #22
Evening people have 83% higher depression risk, while gut bacteria shape your body clock
9 weeks ago7 studies
explore the archive
See more issues from the circadian biology brief