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The differential coupling of oxytocin receptors to uterine contractions in murine estrous cycle
How Oxytocin Receptors Affect Uterine Contractions Differently Across the Mouse Reproductive Cycle
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Abstract
Uterine contractions in response to oxytocin were significantly larger during the estrous phase compared to the diestrous phase.
- The uterus showed no contractions in response to oxytocin during the diestrous phase.
- Numerous contractions were observed in the uterus during the estrous phase following oxytocin administration.
- The potency of oxytocin, as indicated by pD(2) values, differed significantly between the two ovulatory phases.
- Oxytocin receptor levels were similar in the uterus during both phases, suggesting other regulatory mechanisms are involved.
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