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Infusion of oxytocin induces successful delivery in prostanoid FP-receptor-deficient mice
Oxytocin infusion helps mice without a specific prostaglandin receptor give birth successfully
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Abstract
Oxytocin (OT) infusion at 3 U/day enabled successful delivery in prostaglandin F2alpha receptor knockout mice.
- A significant increase in oxytocin receptor levels in the myometrium may be crucial for inducing and completing parturition.
- In prostaglandin F2alpha receptor knockout mice, oxytocin-induced myometrial contractions were similar to those in wild-type mice despite low oxytocin receptor expression.
- Higher doses of oxytocin accelerated the onset of labor in prostaglandin F2alpha receptor knockout mice.
- Plasma progesterone levels remained high in prostaglandin F2alpha receptor knockout females but decreased during labor with oxytocin infusion.
- These findings suggest that oxytocin can induce strong uterine contractions even with low oxytocin receptor expression.
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