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Oxytocin and estrogen receptor levels in the pregnancy muscle layer of mice lacking relaxin
Updated
Abstract
Relaxin decreases oxytocin-stimulated contractions in the myometrium.
- Pregnant relaxin-deficient mice showed significantly decreased oxytocin receptors in the myometrium compared to normal mice on gestation day 18.5.
- An increase in estrogen receptor alpha was correlated with a decrease in estrogen receptor beta in normal mice at term, but this pattern was absent in relaxin-deficient mice.
- Relaxin treatment in relaxin-deficient mice did not impact the expression of oxytocin receptors, LGR7, or estrogen receptor alpha.
- However, relaxin treatment did lead to a significant decrease in estrogen receptor beta levels.
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