Myometrial oxytocin receptor expression and intracellular pathways.

Jun 28, 2014Minerva ginecologica

Oxytocin Receptors and Cell Signaling in Uterine Muscle

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Circadian BiologyCircadian Biology on OpenScience ↗PubMed ↗

Abstract

Oxytocin receptor expression in the human uterus peaks at labor onset and declines sharply during advanced labor and postpartum.

  • Oxytocin is commonly used in obstetrics to induce labor and prevent postpartum hemorrhage.
  • The sensitivity of the uterus to oxytocin may differ among pregnant women due to variations in oxytocin receptor expression.
  • Oxytocin receptor expression is regulated by factors such as steroid hormones, physical stretching of the uterus, and inflammation.
  • Understanding the regulation of oxytocin receptor expression could provide insights into labor mechanisms.

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