Seminars in reproductive medicine

Control of oxytocin receptors and their signaling activity

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

The expression of the oxytocin receptor (OTR) in the mammalian uterus peaks on the day of delivery.

  • The OTR system is crucial for various reproductive and physiological functions.
  • In rodent species, OTR expression is influenced by factors such as stretch and steroid hormones.
  • In humans, the regulatory mechanisms for OTR expression during gestation are less understood, involving inflammatory-related genes and specific transcription factors.
  • Oxytocin's effects on uterine contractions are mediated by the OTR activating G-proteins, which stimulate phospholipase C activity.
  • This activation increases contraction frequency and enhances the sensitivity of muscle cells to calcium.

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