Effects of 2 Hz Flickering Light on Vision, Eye Structure, and Focus in C57BL/6 Mice

After 4 weeks of flickering light exposure, C57BL/6 mice developed myopia, indicated by increased axial length and altered retinal function.

• Flickering light exposure led to an increase in axial length in the mice, suggesting a change in eye shape associated with myopia.
• Corneal radius of curvature remained constant despite the development of myopia.
• Electroretinogram measurements indicated a reduction in both the implicit time and amplitude of retinal signals, impacting retinal function.
• Full-layer retinal thickness, choroidal thickness, and choroidal blood perfusion decreased at both 2 and 4 weeks following exposure to flickering light.
• The most significant reduction in choroidal blood perfusion was observed in the area around the optic disc, specifically within a radius of 150-450 μm.

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