Full text is available at the source.
Abstract
The hybrid continuous synthesis platform achieves flow rates of up to 20 mL min⁻¹ for the production of lipid nanoparticles.
- A reusable 3D-printed milli-fluidic mixer is integrated with inline membrane extrusion to enhance production efficiency.
- The system's design minimizes clogging risks commonly associated with micro-channels.
- Process reproducibility is improved due to the easy-to-clean nature of the durable materials used.
- The platform allows for single-pass refinement, resulting in high-quality, uniform lipid nanoparticles.
- This approach addresses the scalability and cost-effectiveness challenges of current manufacturing methods.
Simplified