Neurological research

A serotonin receptor pathway in the brain's emotion center may influence depression-like behavior in a rat model of Parkinson's disease

Circadian Biology Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

Unilateral 6-hydroxydopamine lesions of the substantia nigra in rats resulted in depressive-like behaviors.

  • The serotonin receptor-adenylate cyclase-protein kinase A signal pathway in the lateral habenula may regulate depressive-like behaviors.
  • Injections of the serotonin receptor agonist CP93129 produced antidepressant-like effects, while the antagonist SB216641 induced depressive-like behaviors.
  • CP93129 decreased the firing rate of lateral habenula neurons and reduced the release of GABA and glutamate, increasing the GABA/glutamate ratio.
  • In substantia nigra-lesioned rats, the effects of CP93129 and SB216641 on behaviors and neurophysiology were diminished.
  • Depletion of dopamine is associated with reduced activity of the serotonin receptor-adenylate cyclase-protein kinase A signal pathway.

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