We can’t show the full text here under this license. Use the link below to read it at the source.
5-HT2A and 5-HT2C Receptors Exert Opposing Effects on Locomotor Activity in Mice
Two serotonin receptors have opposite effects on movement in mice
AI simplified
Abstract
DOI produced an inverted U-shaped dose-response function, with lower doses (0.625-5.0 mg/kg) increasing and higher doses (≥10 mg/kg) decreasing locomotor activity.
- The increase in locomotor activity induced by 1.0 mg/kg DOI was absent in mice lacking 5-HT(2A) receptors, indicating their involvement.
- The reduction in locomotor activity caused by 10 mg/kg DOI was enhanced in 5-HT(2A) receptor knockout mice.
- Pretreatment with a selective 5-HT(2C/2B) antagonist reduced the decrease in locomotor activity from 10 mg/kg DOI, suggesting mediation by 5-HT(2C) receptors.
- A selective 5-HT(2C) agonist produced decreased locomotor activity that was amplified in 5-HT(2A) knockout mice.
- These findings indicate that both 5-HT(2A) and 5-HT(2C) receptors contribute to the effects of DOI on locomotor activity, potentially exerting opposing influences.
AI simplified