Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology

Two serotonin receptors have opposite effects on movement in mice

Psychedelic Science Weekly Brief ↗PubMed ↗DOI ↗

Updated

Abstract

DOI produced an inverted U-shaped dose-response function, with lower doses (0.625-5.0 mg/kg) increasing and higher doses (≥10 mg/kg) decreasing locomotor activity.

  • The increase in locomotor activity induced by 1.0 mg/kg DOI was absent in mice lacking 5-HT(2A) receptors, indicating their involvement.
  • The reduction in locomotor activity caused by 10 mg/kg DOI was enhanced in 5-HT(2A) receptor knockout mice.
  • Pretreatment with a selective 5-HT(2C/2B) antagonist reduced the decrease in locomotor activity from 10 mg/kg DOI, suggesting mediation by 5-HT(2C) receptors.
  • A selective 5-HT(2C) agonist produced decreased locomotor activity that was amplified in 5-HT(2A) knockout mice.
  • These findings indicate that both 5-HT(2A) and 5-HT(2C) receptors contribute to the effects of DOI on locomotor activity, potentially exerting opposing influences.

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Funding

Competing interests

DISCLOSURE/CONFLICT OF INTEREST. The authors declare that over the past three years Mark Geyer has received compensation from Abbott, Acadia, Addex, Amgen, AstraZeneca, Bristol-Myers Squibb, Jazz, Omeros, Organon, Serono, and Wyeth-Ayerst and holds an equity interest in San Diego Instruments (San Diego, CA). Adam Halberstadt, Jay Gingrich, Iris van der Heijden, Michael Ruderman, Victoria Risbrough, and Susan Powell have no conflict of interest, financial or otherwise, to declare.
PubMed

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