Chinese medical journalSep 15, 2026

Psilocybin can reduce fear and promote brain plasticity in mice without activating 5-HT2A receptors

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Updated Sep 16, 2026

Abstract

Psilocybin is associated with fear extinction in rodents.

The hallucinogenic effects of psilocybin are linked to the activation of the 5-HT2A receptor.
Exploration of the role of the 5-HT2A receptor may determine its necessity for the fear extinction effects of psilocybin.
The study investigates psilocybin's potential effects on neuroplasticity related to fear extinction.

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