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Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior
Lower levels of α5GABAA receptors linked to autism-like changes in brain waves and sleep patterns
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Abstract
Gabra5 mice exhibited elevated 0-2Hz EEG activity during all sleep-wake states compared to wild-type controls.
- Gabra5 mice (n=3) showed decreased 8-12Hz EEG activity during REM sleep (p=0.04).
- Sleep spindles were reduced in Gabra5 mice under baseline conditions compared to wild-type mice (n=4) (all p≤0.03).
- Treatment with lipopolysaccharide (LPS) altered EEG activity and sleep-wake behavior in Gabra5 mice, but effects were similar to those observed in wild-type mice.
- These findings support the idea that reduced α5GABAR activity is associated with an autism-like phenotype.
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