We can’t show the full text here under this license. Use the link below to read it at the source.
8-Methoxybicolosin C from Lespedeza bicolor Attenuates Inflammation and Oxidative Stress via Nrf2/HO-1 and NF-κB/MAPK Pathways in Lipopolysaccharide-Induced Mouse Kupffer Cells
8-Methoxybicolosin C from Lespedeza bicolor reduces inflammation and oxidative stress in mouse liver immune cells through antioxidant and inflammation-related pathways
AI simplified
Abstract
8-methoxybicolosin C (8-MC) significantly suppresses inflammation-related mediators in a dose-dependent manner.
- 8-MC reduces the expression of inducible nitric oxide synthase (iNOS) and pro-inflammatory cytokines such as tumor necrosis factor (TNF)-α and interleukins (IL)-6 and IL-1β.
- The compound enhances the balance of glutathione by increasing levels of reduced glutathione (GSH) and decreasing oxidized glutathione (GSSG).
- 8-MC binds to Keap1, which may prevent the degradation of Nrf2, leading to higher expression of antioxidant proteins like heme oxygenase-1 (HO-1).
- It inhibits inflammatory signaling pathways, including c-Jun N-terminal kinases (JNKs) and p38 mitogen-activated protein kinases (MAPKs), and reduces the nuclear translocation of nuclear factor kappa B (NF-κB).
- These findings suggest that 8-MC has strong anti-inflammatory and antioxidant effects through modulation of key signaling pathways.
AI simplified