Abuse Liability Profile of Three Substituted Tryptamines

DIPT, 5-MeO-DET, and 5-MeO-AMT exhibited significant behavioral effects in trained rats, with ED(50) values of 1.71 mg/kg and 0.41 mg/kg for DIPT and 5-MeO-DET, respectively.

• DIPT fully substituted in rats trained to recognize DMT and DOM, but only partially for LSD.
• 5-MeO-DET fully substituted for DMT and showed moderate substitution for MDMA.
• 5-MeO-AMT did not fully substitute for any training drugs but produced notable LSD-appropriate responding.
• None of the compounds substituted in rats trained to distinguish cocaine or methamphetamine.
• All three compounds showed activity at serotonin receptors and inhibited the serotonin transporter.
• DIPT and 5-MeO-DET may pose abuse risks similar to known hallucinogens, with potential hazards at high doses.

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