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Accelerated Biological Aging and Longitudinal Progression of Cardiometabolic Disease, Subsequent Dementia, and Death: A Multistate Analysis
Faster Biological Aging Linked to the Progression of Heart and Metabolic Diseases, Later Dementia, and Death Over Time
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Abstract
Over a median follow-up of 13.7 years, 47,150 participants developed cardiometabolic disease (CMD).
- Biologically older participants showed higher risks of progressing from health to CMD, then to post-CMD dementia, and ultimately to death.
- Each standard deviation increase in KDM- acceleration was associated with a 34% higher risk of transitioning from baseline to CMD.
- acceleration was linked to a 19% increased risk of moving from baseline to CMD.
- KDM-BA acceleration was associated with a 12% increased risk of transitioning from CMD to post-CMD dementia.
- Both BA accelerations were more strongly linked to the transition from CMD to post-CMD vascular dementia compared to post-CMD Alzheimer's disease.
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Key numbers
1.34
Increase in CMD Risk
Adjusted hazard ratio for KDM- acceleration from baseline to CMD.
1.12
Transition to Post-CMD Dementia Risk
Adjusted hazard ratio for KDM- acceleration from CMD to post-CMD dementia.
1.22
Post-CMD VaD Transition Risk
Adjusted hazard ratio for KDM- acceleration from CMD to post-CMD vascular dementia.