We can’t show the full text here under this license. Use the link below to read it at the source.
Biological Age Acceleration, Genetic Susceptibility, and Incident Glaucoma Risk
Faster Biological Aging, Genetic Risk, and New Cases of Glaucoma
AI simplified
Abstract
After a median follow-up of 13.5 years, 6,553 participants developed glaucoma.
- is associated with an increased risk of developing glaucoma.
- Each 5-year increment in biological age acceleration corresponds to a higher glaucoma risk (KDM-BA , 1.12; PhenoAge HR, 1.09).
- Participants who are biologically older have a greater risk of glaucoma compared to younger individuals (KDM-BA HR, 1.10; PhenoAge HR, 1.07).
- Genetic predisposition modifies the association between biological age acceleration and glaucoma risk.
- Biologically older participants with high genetic risk exhibit the highest glaucoma risk (KDM-BA HR, 2.33; PhenoAge HR, 2.21).
- No causal relationships were identified in the Mendelian randomization analysis.
AI simplified
Key numbers
1.12
Increase in Glaucoma Risk per 5-Year Increment
for KDM-BA acceleration
1.10
Higher Glaucoma Risk for Biologically Older Participants
for biologically older vs. younger participants
2.33
Increased Glaucoma Risk with High Genetic Risk
for biologically older participants with high genetic risk