Accelerated Biological Aging, Genetic Predisposition, and Incident Valvular Heart Disease

During a median follow-up of 13.58 years, 8,146 cases of valvular heart disease (VHD) were documented among 341,460 participants.

• Older biological age, as measured by the Klemera-Doubal method, is associated with a 35% increased risk of VHD for each 1-standard deviation increase in biological age acceleration.
• An association is observed between PhenoAge acceleration and VHD, resulting in a 29% increased risk for each 1-standard deviation increase.
• Individuals in the highest quartile of KDM-BA acceleration have an 86% higher risk of developing VHD compared to those in the lowest quartile.
• There is an additive interaction between KDM-BA acceleration and polygenic risk scores, suggesting a combined effect on VHD risk.
• Similar associations are found between PhenoAge acceleration and the risk of VHD.

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