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Associations of combined accelerated biological aging and genetic susceptibility with incident dementia: a prospective study in the UK Biobank
Links between faster biological aging, genetic risk, and new cases of dementia in UK adults
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Abstract
Individuals in the highest quartile of accelerated biological aging had a higher risk of dementia compared to those in the lowest quartile (HR: 1.145).
- Accelerated biological aging, as measured by , is associated with an increased incidence of dementia.
- Biologically older individuals have a higher risk of dementia than biologically younger individuals (HR: 1.069).
- Individuals with biologically younger and high APOE ε4-related genetic risk have a greater risk of dementia than those who are biologically older with the same genetic risk (HR: 3.048 vs. HR: 2.765).
- Among biologically younger individuals, those with a high (PRS) exhibit a 72.7% increased risk of dementia (HR: 1.727) compared to those with a low PRS.
- Biologically older individuals with a high PRS have a 58.7% increased risk of dementia (HR: 1.587) compared to those with a low PRS.
- Negative interactions between accelerated biological aging and APOE ε4-related genetic risk as well as PRS suggest that biological aging may influence genetic susceptibility to dementia.
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Key numbers
1.145
Increase in dementia risk
Hazard Ratio for highest vs. lowest quartile of
3.048×
Higher risk for biologically younger individuals
Hazard Ratio for biologically younger with high APOE ε4-related risk
1.727
Increase in dementia risk with high
Hazard Ratio for biologically younger with high