Full text is available at the source.
Abstract
Essence
Activity-based co-selection made base editor mutational screens cleaner by enriching cells with high editing activity.
Evidence
A base-editing platform experiment developed the co-selection method and compared it with a traditional screen using tiled guide RNAs across TP53.
Caveat
The abstract demonstrates one target-locus benchmark and anticipates broader use, so general performance across other loci and applications remains untested here.
Simplified
CRISPR Gene Editing