British journal of pharmacology

Immediate allergic and widespread inflammation effects of Comirnaty in pigs linked to spike protein mRNA and increased inflammatory signals

Updated

Abstract

Rare but severe adverse events (AEs) associated with mRNA-lipid nanoparticle (LNP) COVID-19 vaccines include anaphylaxis and inflammatory organ disorders.

  • The underlying mechanisms of these adverse events are poorly understood.
  • An animal model is being developed to study these severe adverse effects.
  • Understanding these mechanisms may help in addressing safety concerns related to COVID-19 vaccines.

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