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The acute anorexic effect of liraglutide, a GLP-1 receptor agonist, does not require functional leptin receptor, serotonin, and hypothalamic POMC and CART activities in mice
Liraglutide’s short-term appetite loss in mice does not depend on leptin receptors, serotonin, or key hunger-related brain signals
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Abstract
Liraglutide produces an acute decrease in appetite that may be linked to reduced hypothalamic orexin activity.
- The anorexic effect of liraglutide does not depend on functional leptin receptors or serotonin activity.
- Activities of proopiomelanocortin and cocaine amphetamine regulated transcript in the hypothalamus are not required for this effect.
- There is a potential involvement of decreased hypothalamic orexin activity in liraglutide's appetite-suppressing effects.
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