Liraglutide’s short-term appetite loss in mice does not depend on leptin receptors, serotonin, or key hunger-related brain signals

Liraglutide produces an acute decrease in appetite that may be linked to reduced hypothalamic orexin activity.

• The anorexic effect of liraglutide does not depend on functional leptin receptors or serotonin activity.
• Activities of proopiomelanocortin and cocaine amphetamine regulated transcript in the hypothalamus are not required for this effect.
• There is a potential involvement of decreased hypothalamic orexin activity in liraglutide's appetite-suppressing effects.

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