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Different measures of how psychedelics quickly change brain signal complexity on fMRI
Updated
Abstract
In a study of 28 healthy participants, 121 pre- and post-psilocybin fMRI scans revealed significant positive associations for several brain entropy metrics.
- Psychedelics may increase brain entropy, but specific metrics yield different results.
- Significant positive associations were found for Shannon entropy, path-length, instantaneous correlations, brain-state switching, and sample entropy at short time-scales.
- No significant effects were observed for 8 of the 14 entropy metrics evaluated.
- Inconsistent positive effects were noted for Lempel-Ziv complexity of the BOLD signal.
- Limited inter-measure correlations suggest that brain entropy quantifications do not represent a single construct.
Simplified
Psychedelic Science