Association of adiponectin gene polymorphism rs266729 with type two diabetes mellitus in Iraqi population. A pilot study

The frequency of the G allele of rs266729 was significantly higher in diabetic subjects (28%) compared to healthy subjects (14%).

• The homozygous genotype (GG) is associated with a threefold increase in the risk of type 2 diabetes mellitus (T2DM) compared to the wild type (CC).
• The heterozygous genotype (CG) is associated with a twofold increase in the risk of T2DM.
• Both homozygous and heterozygous genotypes of rs266729 are linked to elevated fasting insulin levels.
• These genotypes are also associated with decreased levels of HDL cholesterol.
• The adiponectin gene polymorphism rs266729 may be involved in the pathogenesis of T2DM and could influence cardiovascular diseases and metabolic syndrome.

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