Causal association between adiponectin and risk of trigeminal neuralgia: A Mendelian randomization study

Feb 8, 2024Clinical neurology and neurosurgery

Possible link between adiponectin levels and risk of trigeminal nerve pain

AI simplified

Circadian Biology on OpenScience ↗PubMed ↗DOI ↗

Abstract

A causal association between adiponectin levels and trigeminal neuralgia risk was observed with an odds ratio of 0.577.

Analysis utilized data from 39,883 individuals for adiponectin and 195,847 for trigeminal neuralgia.
Four different statistical methods were used to assess the relationship between adiponectin and trigeminal neuralgia.
The inverse variance-weighted method indicated a significant causal link between higher adiponectin levels and reduced trigeminal neuralgia risk.
Weighted median and weighted mode approaches also supported a causal association, with odds ratios of 0.569 and 0.586, respectively.
No evidence of bias or directional pleiotropy was found in the analysis.

AI simplified

OBJECTIVE: To determine whether adiponectin levels and the risk of trigeminal neuralgia (TN) were causally related, a two-sample Mendelian Randomization (MR) study design was used.

METHODS: We obtained data regarding adiponectin from the UK Biobank genome wide association studies (GWAS) (n = 39,883) as the exposure and TN, using GWAS summary statistics generated from FinnGen, (total n = 195 847 159; case = 800, control = 195 047) as the outcome. We conducted a two-sample Mendelian randomization analysis employing inverse variance-weighted (IVW), MR-Egger regression, weighted median, and weighted mode analyses.

RESULTS: We selected 14 single nucleotide polymorphisms (SNPs) with genome-wide significance from the GWAS on adiponectin as instrumental variables. Based on the IVW method, a causal association between adiponectin levels and TN was evidenced (OR= 0.577, 95 %CI: 0.393-0.847). MR-Egger regression revealed that directional pleiotropy was unlikely to be biasing the result (intercept = -0.01; P = 0.663), but it showed no causal association between adiponectin and TN (OR=0.627, 95 %CI: 0.369-1.067). However, the weighted median (OR=0.569, 95 %CI: 0.353-0.917) and Weighted mode (OR= 0.586, 95 %CI: 0.376-0.916) approach yielded evidence of a causal association between adiponectin and TN. Cochran's Q-statistics and funnel plots indicated no evidence of heterogeneity or asymmetry, indicating no directional pleiotropy.

CONCLUSION: The results of the MR analysis suggested that adiponectin may be causally associated with an increased TN risk.

Full Text

Full text is available at the source.

View full text (XML) ↗View full text ↗

Causal association between adiponectin and risk of trigeminal neuralgia: A Mendelian randomization study

Abstract

Full Text

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief

Abstract

Full Text

Related papers

You found one interesting study. We’ll send the next 7.

what lands in your inbox each week:

Recent issues from the circadian biology brief