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How fat tissue may contribute to age-related inflammation
Updated
Abstract
Aging is associated with significant changes in white adipose tissue, including an increase in visceral fat and a decline in gluteofemoral subcutaneous fat.
- White adipose tissue undergoes dysfunction characterized by increased inflammatory peptide production and reduced anti-inflammatory activity.
- There is a decline in the differentiation of preadipocytes, which are crucial for maintaining healthy fat tissue.
- Aging is linked to increased oxidative stress and mitochondrial dysfunction within white adipose tissue.
- Vascularization decreases, and there is an accumulation of senescent cells and fibrosis in aging white adipose tissue.
- These changes in white adipose tissue may contribute to a systemic pro-inflammatory state known as 'inflammageing,' associated with age-related metabolic alterations.
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