Adjunctive triple chronotherapy (combined total sleep deprivation, sleep phase advance, and bright light therapy) rapidly improves mood and suicidality in suicidal depressed inpatients: An open label pilot study

In a pilot trial with 10 suicidal inpatients, combined total sleep deprivation, sleep phase advance, and bright light therapy led to a significant reduction in depression and suicidality scores.

• Hamilton depression scale scores decreased from a mean of 24.7 to 9.4 after five days of treatment.
• Six out of ten participants met the criteria for remission by the end of the protocol.
• Columbia Suicide Severity Rating Scale scores dropped from a mean of 19.5 to 7.2 during the same period.
• The intervention was reported to be feasible and tolerable among participants.
• Limitations include the small sample size and lack of a comparison group.

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