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β‐Adrenergic receptors control brown adipose UCP‐1 tone and cold response without affecting its circadian rhythmicity
Beta-adrenergic receptors regulate brown fat activity and cold response without changing its daily rhythm
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Abstract
β-adrenergic receptors (βARs) are essential for maintaining basal Ucp1 expression in brown adipose tissue at room temperature.
- Ucp1 gene expression is significantly induced by cold temperatures through βAR signaling.
- Mice lacking βARs exhibit low basal Ucp1 expression, indicating βARs' role in its maintenance.
- Despite low Ucp1 levels in β-less mice, the circadian patterns of Ucp1 and clock genes remain intact.
- βAR signaling is crucial for the normal circadian rhythms of locomotor activity.
- The study highlights the independent roles of βAR signaling in thermogenic response and circadian rhythmicity in brown adipose tissue.
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