Psychiatry research

Reported side effects of classic psychedelics and MDMA in the general population using WHO safety data

Updated

Abstract

Essence

Reports to VigiBase linked MDMA and LSD most strongly with psychiatric and substance-use adverse-event signals.

Evidence

This exploratory pharmacovigilance analysis used WHO VigiBase spontaneous reports for MDMA, LSD, psilocybin, DMT, and mescaline, with acetaminophen and oxycodone comparators.

Caveat

Spontaneous reports cannot establish incidence or causality, and interpretation is limited by co-use of other substances and likely underreporting of illicit drug use.

Simplified

Full Text

Full text is available at the source.

Funding

Competing interests

Declaration of competing interest OAS reports no conflicts of interest with the current work. SMN has received research support from Brain Canada, CIHR, the Brain and Behaviour Research Foundation, and the Tory Trauma Program at Sunnybrook Health Sciences Centre. He reports no conflicts of interest with the current work. MIH receives research support from CIHR, CAMH Foundation, and the University of Toronto. He leads contracted research for COMPASS Pathways Limited and has provided consultancy to Mindset Pharma, Neurocentrx and Otsuka Pharmaceuticals. He reports no conflicts of interest with the current work. MS receives research salary support from the Sunnybrook Health Sciences Centre (Department of Psychiatry). He reports no conflicts of interest with the current work. FA has recieved research grants from PSI and Sunnybrook AFP. He is the co-founder of the Ontario Ketamine and Infusion Clinic. He reports no conflicts of interest with the current work. PG has received grants in the area from CIHR and the PSI Foundation. He recieves salary support from the Kerr Chair in Interventional Psychiatry. He reports no conflicts of interest with the current work.
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