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Adverse events in clinical treatments with serotonergic psychedelics and MDMA: A mixed-methods systematic review
Side effects of serotonin-related psychedelics and MDMA in medical treatments: a combined review
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Abstract
A total of 598 unique patients were included in a review of associated with psychedelics and MDMA.
- The review encompassed 44 articles, consisting of 34 quantitative and 10 qualitative studies.
- Commonly reported acute adverse events included nausea, headaches, and anxiety across various diagnoses and substances.
- Late adverse events reported involved headaches, fatigue, low mood, and anxiety, particularly with MDMA.
- One serious adverse event, an increase in premature ventricular contractions, required brief hospitalization during MDMA treatment.
- There is a possibility that psychologically challenging experiences during treatment could have therapeutic benefits.
- Adverse events are likely underreported due to inadequate assessment methods and study design.
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Key numbers
44
Total Studies
Total number of studies analyzed for .
598
Unique Patients
Total unique patients treated with psychedelics or MDMA.
56%
Prior Experience
Percentage of patients with prior psychedelic use in MDMA studies.