BMJ open

Mouth-related side effects of drugs that activate GLP-1 and GIP receptors: review plan

Updated

Abstract

Emerging data suggest that glucagon-like peptide-1 receptor agonists and dual incretin receptor agonists may lead to oral adverse effects.

  • There is a potential association between glucagon-like peptide-1 receptor agonists and oral issues such as dry mouth, altered taste, and throat discomfort.
  • Alterations in salivary function could increase the risk of dental problems and oral tissue irritation.
  • Metabolic and inflammatory changes from these medications may indirectly impact oral health.
  • Current evidence on the oral manifestations of these treatments is limited and inconsistently reported.
  • Further investigation is necessary to understand the prevalence and significance of these oral effects.

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Full Text

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