Age-specific differential changes on gut microbiota composition in patients with major depressive disorder

Feb 11, 2020Aging

Age-related differences in gut bacteria in people with major depression

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Abstract

In total, 70 patients with major depressive disorder (MDD) were compared to 71 healthy controls.

  • Significant differences in gut microbiota composition were observed between young MDD patients and young healthy controls.
  • In young MDD patients, specific bacterial populations were significantly decreased compared to healthy peers.
  • In middle-aged MDD patients, different bacterial populations were significantly altered when compared to middle-aged healthy controls.
  • Six different bacterial types were identified as differentially abundant in young MDD patients, while 25 were noted in middle-aged MDD patients.
  • Age-specific changes in gut microbiota composition may be associated with major depressive disorder.

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