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Abstract
A senescent vascular niche after bone injury could negatively impact mesenchymal stem cell function.
- Local microenvironments may influence the effectiveness of mesenchymal stem cells in healing bone defects.
- Age-related or injury-induced cellular senescence is associated with compromised stem cell function.
- The study examines how a senescent vascular environment affects stem cell growth and development.
- Potential mechanisms involved in regeneration and removal of the aging microenvironment are investigated.
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